Involvement of Galectin-1 and Galectin-3 in Proliferation and Migration of Rat Hepatic Stellate Cells in Culture
نویسندگان
چکیده
Address: 1Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan, 2Department Anatomy, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan, 3Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8397, Japan, 4Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-0195, Japan and 5Department of Biological Science, Graduate School of Science, Hiroshima University, Hiroshima 739-8526, Japan
منابع مشابه
Galectin-1 induces chemokine production and proliferation in pancreatic stellate cells.
Galectin-1 is a beta-galactoside-binding lectin. Previous studies have shown that galectin-1 was expressed in fibroblasts of chronic pancreatitis and of desmoplastic reaction associated with pancreatic cancer. These fibroblasts are now recognized as activated pancreatic stellate cells (PSCs). Here, we examined the role of galectin-1 in cell functions of PSCs. PSCs were isolated from rat pancrea...
متن کاملImmunolocalization of Galectin-3 in Mouse Testicular Tissue
Objective(s) Galectin-3 (Gal-3) is a member of the B-galactoside-binding lectins which is expressed in a variety of tissues and plays a role in diverse biological events, such as embryogenesis, adhesion, cellular proliferation, and apoptosis. In this study, the presence and distribution of galectin-3 (Gal-3) in the mouse testicular tissue was investigated. Materials and Methods Eight adult N...
متن کاملبررسی رابطه بیان مارکر گالکتین 3 با میزان بقاء و ویژگی های بالینی آسیب شناسی در بیماران مبتلا به سرطان کولورکتال
Background and purpose: Some factors are involved in progression and metastasis in colorectal cancer with same differentiation and invasion. Galectin-3 is one suspected factor which has the capacity to self–review and to differentiate to carcinoma cells. This study has evaluated the association of Galectin-3 expression with clinicopathologic features and survival in patients with colorectal can...
متن کاملO-36: The Role of Galectin-3 in Rat CorpusLuteum Maintenance
Background: Galectin, an animal lectin that recognizes b-galactosides of glycoconjugates, is involved in multiple biological functions such as cell growth, differentiation, apoptosis, signal transduction and angiogenesis. Overexpression of galectin-3 was observed in different tumors which was related to pro-angiogenic activity. In addition, galectin-3 is intensely expressed in corpus luteum (CL...
متن کاملGalectin-3 regulates myofibroblast activation and hepatic fibrosis.
Central to fibrogenesis and the scarring of organs is the activation of fibroblasts into matrix-secreting myofibroblasts. We demonstrate that Galectin-3 expression is up-regulated in established human fibrotic liver disease and is temporally and spatially related to the induction and resolution of experimental hepatic fibrosis. Disruption of the Galectin-3 gene blocks myofibroblast activation a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Comparative Hepatology
دوره 3 شماره
صفحات -
تاریخ انتشار 2004